Amyl cresols and preparation thereof



Patented Aug. 15, 1933 UNITED STATES PATENT OFFICE- AMYL CBESOLS AND PREPARATION THEREOF York No Drawing. Application January 15, 1932 Serial N0. 586,956

2 Claims.

This invention relates to amyl cresols, and has for its object the provision of (1) an advantageous method of preparing amyl cresols generally and (2) a bactericidally active mixture of 5 isomeric amyl cresols.

Essentially the method of this invention comprises condensing a cresol with an amylene, such cresol and such amylene being chosen as correspond to the respective constituents of the amyl cresol desired. It commercial amylene, a mixture of isomers, is used, there results a mixture of isomeric amyl cresols, characterized by bactericidal activity of a high order.

For example, to 400 cc. of sulfuric acid cooled to 15 C. by means of carbon-dioxide ice in alcohol, 200 g. of ortho-cresol dissolved in 400 cc. of ether is added, mechanical agitation being used and the temperature being kept below 5 C. A solution of .200 g. of commercial amylene in 200 cc. of ether is added in small portions during the course of half an hour, and the mixture is thereafter stirred for two hours, a temperature of between 15 and -5 C. being maintained throughout. Now the temperature is allowed to rise to 0 C. and the reaction mixture is poured into several times its weight of crushed ice. The ether layer is separated outand washed with dilute sodium bicarbonate solution, and the ,various other ormsfor instance as to the parat a temperature of not more than about 10 C.

ticular cresols and amylenes and procedures emplayed-within the scope or the appended claims.

We claim: 1. The method of preparing amyl cresol that comprises condensing a cresol with an amylene in the presence ofsulfuric acid.

2. The method of preparing a mixture of isomeric amyl cresols that comprises condensing a cresol with commercial amylene at a temperature of not more than about 10 C.-in the presence of sulfuric acid.

WALTER G. nmsmnsnu. WILLIAM A. mm. 

